| Chapter 1. Why Should Oncology Nurses Be Interested in Genetics? |
1 |
| The Impact of Advancements in Genetics on the Oncology Nurse's Role |
2 |
| Genetic Health Care and Oncology Nursing |
4 |
| How Is Genetic Information Different? |
5 |
| How Will Genetic Information Be Incorporated Into General Health Care? |
6 |
| What Role Will Nurses Play in Meeting the Genetic Healthcare Needs of the Future? |
7 |
| Are You Using Genetic Information Yet? |
8 |
| Quiz: How Frequently Do You Use or Provide Genetics Information? |
8 |
| Chapter 2. The Scope of Cancer Genetics Nursing Practice |
13 |
| Dimensions of Cancer Genetics Nursing Practice |
14 |
| Role of the Nurse in Integrating Genetics Into Oncology Practice |
15 |
| Scope of Practice |
16 |
| Opportunities for Collaboration |
21 |
| Incorporation of Cancer Genetics in Various Practice Settings |
21 |
| Chapter 3. The Biology of Cancer |
23 |
| Introduction |
23 |
| DNA and Chromosomes: Structure and Function |
24 |
| Gene Expression |
27 |
| Causes of Mutations |
29 |
| Types of Mutations Associated With Cancer |
29 |
| Gene Transmission in Cancers |
32 |
| Genes Implicated in Cancers |
32 |
| Types of Genetic Alterations in Cancer Cells |
47 |
| The Cell Cycle |
50 |
| Apoptosis |
52 |
| Tumorigenesis |
52 |
| Chapter 4. How to Perform a Genetic Assessment |
57 |
| What Is a Genetic Assessment for Cancer? |
57 |
| What Is the Purpose of a Genetic Assessment? |
58 |
| What Are the Specific Components of a Genetic Assessment? |
58 |
| The Assessment Process |
67 |
| Confidentiality and Genetic-Risk Assessment Records |
70 |
| Common Problems of Genetic Evaluation |
70 |
| Models to Facilitate Risk Assessment |
71 |
| A Sample Assessment |
71 |
| Chapter 5. Cancer-Risk Assessment: Considerations for Cancer Genetics |
77 |
| Introduction |
77 |
| Terms Commonly Used in Risk Assessment |
78 |
| General Limitations of Risk Assessment |
83 |
| Major Types of Risk |
85 |
| Prediction Models and Criteria |
90 |
| The Importance of Knowledge to Risk Assessment |
101 |
| Communication of Risk Assessment |
102 |
| Techniques for Communicating Cancer-Risk Assessments |
105 |
| Tools for Communicating Risk |
110 |
| The Impact of the Client's Beliefs |
113 |
| The Challenge of Uncertainty |
118 |
| Navigating Statistics |
120 |
| Promoting Screening and Prevention |
120 |
| The Media's Role in Risk Information |
121 |
| The Long-Term Impact of Risk Communication |
123 |
| Risk-Assessment Documentation |
124 |
| Annual Assessment Updates |
128 |
| The Implications of Screening Tests |
128 |
| Nursing Implications of Risk Assessment |
129 |
| The Need for Future Research |
130 |
| Chapter 6. The Impact of Genetic Information in the Management of Cancer |
139 |
| Introduction |
139 |
| Risk Management and Cancer Prevention |
140 |
| Diagnosis and Prognosis |
156 |
| Treatment |
163 |
| Chapter 7. How to Provide Genetic Counseling and Education |
189 |
| Genetic Counseling |
189 |
| Counseling Issues Related to Genetic Information |
190 |
| Cancer-Predisposition Testing: Who Might Benefit? |
197 |
| Types of Test Results |
200 |
| Implications of Test Results |
201 |
| Interpreting Test Results |
205 |
| What to Do After Testing |
205 |
| Cancer Surveillance and Risk Reduction |
206 |
| The Three-Component Counseling Model |
207 |
| Tips for Information Delivery |
210 |
| Ethical and Legal Issues |
212 |
| Documents Usually Found in a Cancer Genetics Medical Record |
219 |
| Chapter 8. Establishing a Cancer Genetics Clinic |
225 |
| Introduction |
225 |
| Program Needs Assessment |
226 |
| Types of Cancer Genetics Programs |
227 |
| Clinical Program Components |
230 |
| Operational Issues |
233 |
| Client Recruitment |
237 |
| Client Resources |
237 |
| Professional Resources |
238 |
| Chapter 9. Handling Genetic Information Responsibly |
243 |
| Introduction |
243 |
| Ethical Considerations of Genetic Information |
244 |
| Recognition of Personal Biases and How Values Affect Others' Decisions |
248 |
| Facilitating Autonomous Decision Making |
250 |
| Principles of Beneficence and Nonmaleficence |
251 |
| Recognition of Ethnocultural Differences |
252 |
| Privacy and Confidentiality |
253 |
| Client Advocacy |
255 |
| Emerging Ethical Issues for Oncology Nurses |
256 |
| Maintaining a Current Knowledge Base in Genetic Developments |
257 |
| Chapter 10. How to Identify Appropriate Referrals and Current Resources |
263 |
| Introduction |
263 |
| Resources for Networking and Genetics Information |
263 |
| Sources of Patient Referrals |
270 |
| Resources for Continuing Education |
272 |
| Resources for Information Regarding Genetics and Health Policy |
273 |
| Genetics Legislation |
275 |
| Research Opportunities |
276 |
| Chapter 11. Ensuring Competence: Nursing Credentialing in Cancer Genetics |
279 |
| Introduction |
279 |
| The Significance of Credentialing to Clinical Practice |
280 |
| Measures of Competence |
282 |
| The Availability of Credentialing for Oncology Nurses in Genetics |
284 |
| Chapter 12. Recommendations for Education |
287 |
| Introduction |
287 |
| Recommendations Regarding the Education of the General Oncology Nurse in Practice |
289 |
| Recommendations Regarding the Education of an Advanced Practice Oncology Nurse in Practice |
294 |
| Recommendations Regarding the Education of an Advanced Practice Oncology Nurse With a Subspecialty in Genetics |
301 |
| Conclusion |
311 |
| Suggested Readings |
312 |
| Glossary |
315 |
| Index |
321 |