Multiple Myeloma: A Textbook For Nurses

Buy Book

Foreword xi
Preface xiii
Chapter 1. Introduction 1
What Is Multiple Myeloma? 1
Historical Accounts 1
Nursing Contributions to Myeloma Care 3
Collaboration and Partnership 3
Forging Ahead 4
References 4
Chapter 2. Anatomy and Physiology 9
The Immune System 9
Innate and Acquired Immunity 9
Adaptive Immunity: Humoral and Cellular 10
Organs of the Immune System 11
Cells Responsible for Innate Immunity 11
Cells Responsible for Adaptive Immunity 12
Immunoglobulins 18
Cytokines 21
Conclusion 24
References 25
Chapter 3. Pathophysiology 27
Introduction 27
The Role of Genetics 27
Cytokines 34
Conclusion 38
References 38
Chapter 4. Epidemiology 41
Introduction 41
Etiology 41
Incidence 42
Risk Factors 42
Conclusion 49
References 49
Chapter 5. Patient Assessment 55
Introduction 55
Clinical Manifestations of Multiple Myeloma 55
Diagnosis of Myeloma 61
Staging 63
Diagnostic Tests and Procedures 64
Prognostication 68
Conclusion 72
References 72
Chapter 6. Treatment of Newly Diagnosed, Transplant-Ineligible Patients 77
Introduction 77
A New Era 77
Standard Autologous Stem Cell Transplant 78
A Philosophical Divide 79
Reduced-Intensity Autologous Stem Cell Transplant 80
Conventional Therapies 81
Maintenance Therapy 100
Conclusion 103
References 104
Chapter 7. Treatment of Newly Diagnosed, Transplant-Eligible Patients 109
Introduction 109
Single or Tandem Autologous Stem Cell Transplantation 110
Allogeneic Stem Cell Transplantation 116
Nonmyeloablative or Reduced-Intensity Allogeneic Stem Cell Transplantation 117
Maintenance Therapy Following Stem Cell Transplantation 119
Conclusion 120
References 121
Chapter 8. Treatment of Relapsed or Refractory Multiple Myeloma 125
Introduction 125
Symptomatic and Asymptomatic Relapse 130
Imaging in Patients With Relapsed Multiple Myeloma 131
Use of Radiation Therapy in Relapsed Multiple Myeloma 134
The Role of Bisphosphonates 135
Treatment Modalities for Relapsed Multiple Myeloma 137
Conclusion 148
References 148
Chapter 9. Management and Evaluation of Patients Receiving High-Dose Chemotherapy With Stem Cell Transplantation 155
Introduction 155
Patient Evaluation 156
Human Leukocyte Antigen Typing 159
Stem Cell Mobilization 159
Stem Cell Collection 161
Stem Cell Processing and Cryopreservation 162
Stem Cell Transplantation 163
Engraftment or Recovery Phase 165
Conclusion 166
References 170
Chapter 10. Management and Evaluation of Patients Receiving Novel Agents 173
Introduction 173
Thalidomide 173
Lenalidomide 178
Bortezomib 180
Pegylated Liposomal Doxorubicin 183
Future Novel Agents 187
Conclusion 187
References 187
Chapter 11. Patient Teaching 195
Introduction 195
How to Teach 196
What to Teach 204
Conclusion 225
References 225
Chapter 12. Survivorship Issues 231
Introduction 231
Continuum of Care 232
Bone Health and Mobility 233
Renal Function 237
Health Maintenance 241
Psychosocial Issues 242
Conclusion 254
References 254
Chapter 13. Nursing Research 257
Introduction 257
Nursing Research Topics in Multiple Myeloma 258
Gaps in the Literature 264
Future Scenario of Nursing Research in Myeloma 265
Conclusion 265
References 265
Chapter 14. On the Horizon: Future Considerations 267
Introduction 267
Ongoing Research Studies 267
Promising Clinical Trials 268
Cellular and Molecular Genetics 270
Advances in Imaging 271
Conclusion 272
References 272
Index 279
Advertisement