The Case of the CAR T-Cell Toxicity Test

Wilson was diagnosed with B-cell lymphoma three days after his 63rd birthday. He underwent chimeric antigen receptor (CAR) T-cell therapy after his disease failed to respond to two lines of systemic chemotherapy. On day 8 following CAR T-cell therapy, his nurse Becky notices a deterioration in Wilson’s handwriting. She also sees him hesitate when she asks him what hospital he is in and the day of the week, both questions he easily answered the day before. Wilson tells Becky he didn’t sleep well and is just tired.