The Case of the Immunotherapy Inquiry, Part II

You may remember Jay, a 62-year-old man with inoperable stage IIIA non-small cell lung cancer (NSCLC), from the case study in the April 2017 issue of ONS Voice. He was symptomatic with a persistent cough, unintentional weight loss, and fatigue.

Jay completes six weeks of chemoradiation with carboplatin and paclitaxel. His presenting symptoms resolve, and positron-emission tomography (PET) shows no evidence of disease. Unfortunately, a PET 10 months later reveals mediastinal lymphadenopathy, and a biopsy confirms metastatic squamous cell carcinoma. Jay begins treatment with an immune checkpoint inhibitor.