Functional Quality-of-Life Outcomes Reported by Men Treated for Localized Prostate Cancer: A Systematic Literature Review

Hilary Baker, BSc (Hons), RGN; Sandie Wellman, MSc, BSc (Hons), RGN; and Verna Lavender, PhD, PGCE, BSc (Hons), RGN


Problem Identification: To systematically evaluate the literature for functional quality-of-life (QOL) outcomes following treatment for localized prostate cancer.

Literature Search: The MEDLINE®, CINAHL®, EMBASE, British Nursing Index, PsycINFO®, and Web of Science™ databases were searched using key words and synonyms for localized prostate cancer treatments.

Data Evaluation: Of the 2,191 articles screened for relevance and quality, 24 articles were reviewed. Extracted data were tabulated by treatment type and sorted by dysfunction using a data-driven approach.

Synthesis: All treatments caused sexual dysfunction and urinary side effects. Radiation therapy caused bowel dysfunction, which could be long-term or resolved within a few years. Sexual function could take years to return. Urinary incontinence resolved within two years of surgery but worsened following radiation therapy. Fatigue was worse during treatment with adjuvant androgen-deprivation therapy, and some men experienced post-treatment fatigue for several years.

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