Renal, GI, and Peripheral Nerves: Evidence-Based Recommendations for the Management of Symptoms and Care for Patients With Multiple Myeloma

Beth Faiman, PhD, MSN, APRN-BC, AOCN®; Deborah Doss, RN, OCN®; Kathleen Colson, RN, BSN, BS; Patricia Mangan, RN, MSN, APRN-BC; Tracy King, RN, MN; Joseph D. Tariman, PhD, RN, ANP-BC, FAAN


Background: A majority of patients with multiple myeloma experience damage to the kidneys and peripheral nerves either at diagnosis or throughout the disease. Symptoms of diarrhea, nausea, vomiting, or constipation can also occur. Prevention and management of disease- and treatment-related side effects are essential to treatment adherence.

Objectives: This article aims to provide insight into prevention and management of organ health–related toxicities and give best practice recommendations for optimal nursing care.

Methods: The authors performed a literature search, and articles were reviewed for relevance to each organ-related topic: renal, gastrointestinal, and peripheral nerves. 

Findings: Prevention and management strategies include close monitoring and prompt intervention when organ damage develops to reverse impairment and maintain adherence to therapy when indicated.

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