ASCO/ONS Antineoplastic Therapy Administration Safety Standards

The American Society of Clinical Oncology (ASCO) and ONS are conducting an ongoing collaborative project to use a rigorous, consensus-based process to develop standards for the safe administration of antineoplastic medications. Current ASCO/ONS standards address the safety of all routes of antineoplastic medication administration to adult and pediatric patients in all settings.

The ASCO/ONS Antineoplastic Therapy Administration Safety Standards for Adult and Pediatric Oncology are intended to reduce the risk of error when providing patients with antineoplastic therapy, and to provide a framework for best practices in cancer care. Your institution can use them to inform practice policies and procedures, internal quality assessment, and external quality monitoring.

View the 2024 standards.

View the 2016 standards.

View the 2013 standards.

View the 2011 revised standards.

View the original 2009 standards.


In December 2008, ASCO and ONS held a workshop to develop a consensus regarding standards for the safe administration of chemotherapy to adult patients in the outpatient setting. Although relevant guidelines and policy statements existed (e.g., OSHA's Controlling Occupational Exposure to Hazardous Drugs, Chapter 2: Safe Handling of Chemotherapy Drugs, the ONS Chemotherapy and Biotherapy Guidelines and Recommendations for Practice, ASCO's Criteria for Facilities and Personnel for the Administration of Parenteral Systemic Antineoplastic Therapy), specific requirements to promote patient safety had not been well-defined by key stakeholders. The complexity of administration of antineoplastic agents and the potential safety issues involved are unique to oncology care and require careful consideration.


A description of the ASCO/ONS Chemotherapy Administration Safety Standards process for development, consensus, and refinement, as well as a discussion of the standards and results, is available on the ASCO website.

Related Resources

ONS Symptom Interventions and Guidelines

Summaries of evidence and recommendations for the management of cancer-related symptoms and treatment side effects to improve patient outcomes and optimize clinical care delivery.

View All Symptom Interventions and Guidelines