Impact of an Alert System on Quality Indicators in Patients With Acute Promyelocytic Leukemia

Lisa Blackburn

Nicole Bauchmire

Sarah Bender

Kelly Tomlinson-Pinkham

Scott Roberts

Sherry Rosan

acute promyelocytic leukemia, disseminated intravascular coagulation, differentiation syndrome, fibrinogen, all-trans retinoic acid
CJON 2016, 20(5), 523-527. DOI: 10.1188/16.CJON.523-527

Background: Acute promyelocytic leukemia (APL), once the most lethal form of adult acute leukemia, has become the most curable. The goal of early and well-managed treatment induction is to reduce the malignant burden of promyelocytes to below the cytologically detectable level.

Objectives: Oncology nurses who care for patients with APL need to be acutely aware of the basic differences in this disease from other forms of leukemia, including the two main complications for the newly diagnosed patient: disseminated intravascular coagulation and differentiation syndrome.

Methods: This article will briefly review APL and its associated presenting symptoms, prognosis, treatment, and complications.

Findings: These complications require immediate activation of expert staff and resources to protect critically ill patients with APL from associated morbidity and mortality.

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