Lesbian, gay, bisexual, transgender, and queer (LGBTQ) people are diverse, representing a small percentage of the American population. The identities of LGBTQ people are complex, are multilayered, and have a substantial impact on health and well-being. Oncology nurses and allied health professionals are uniquely positioned to appreciate the individuality of each patient, as well as address population-based considerations. This affords the provision of compassionate, culturally, and clinically competent care to this vulnerable population. Oncology care providers can begin to address the health inequities experienced by the LGBTQ community, restore trust in the patient–provider relationship, and improve care quality.