Nurses can inform and lead patient-centered outcomes research (PCOR) projects that address care-related questions prioritized by patients. However, PCOR projects may fail to materialize because time constraints create barriers to forming partnerships for the advancement of research. Even in established relationships, PCOR partners (i.e., physicians, nurses, and patients) may disagree about the relative importance of a research question and how best to engage partners. This article is designed to pique the interest of oncology nurses and reveal opportunities to engage in and colead PCOR projects. It illustrates three fundamental steps to prepare oncology nurses for developing PCOR questions and participating in a PCOR project team.