Prevention of Infection Search Strategy

PREVENTION OF INFECTION SEARCH STRATEGY AND RESULTS
 
Initial references prior to update: 31
 
Databases searched for update: PubMed, CINAHL, NCCN, and Cochrane Collaboration
 
Search results of literature retrieved 1/1/2009–4/29/2015:
  • PubMed
    • ((Therapy/Broad[filter] OR systematic[sb]) AND (("Cross Infection/prevention and control"[MAJR] OR infection control[majr]) AND (cancer OR oncolog* OR neoplasms[majr]))) OR (("Anti-Infective Agents/therapeutic use"[MAJR] OR "Antibiotic Prophylaxis/nursing"[Majr] OR "Antibiotic Prophylaxis/standards"[Majr]) AND (cancer[ti] OR chemotherapy[ti] OR oncol*[ti])) OR (Neutropenia/prevention and control[MAJR]) OR ((Therapy/Broad[filter] OR systematic[sb]) AND (neutropenia[majr] OR neutropen*[ti]) AND (cancer OR oncolog* OR neoplasms[majr] OR chemotherapy*)) OR (Antifungal Agents/therapeutic use[MAJR] AND (cancer OR oncolog* OR neoplasms[majr] OR chemotherap*)) AND ("2009/01/01"[PDAT] : "2015/04/29"[PDAT])
    • 2,478 citations retrieved
  • CINAHL
    • ((MM "Cross Infection/PC" OR MM infection control) AND (cancer OR oncolog* OR neoplasms)) OR ((MM "Antinfective Agents/TU" OR "MM Antibiotic Prophylaxis/NU" OR "MM Antibiotic Prophylaxis/ST") AND (TI cancer OR TI chemotherapy OR TI oncol*)) OR MM “Neutropenia/PC” OR ( (MM neutropenia OR TI neutropen*) AND (cancer OR oncolog* OR neoplasms OR chemotherap*)) OR ( MM “Antifungal Agents/TU” AND (cancer OR oncolog* OR neoplasms OR chemotherap*)) 
    • Limiters: English Language; Clinical Queries: Therapy - High Sensitivity, Therapy - High Specificity, Therapy - Best Balance
    • 319 citations retrieved
  • NCCN
    • National Comprehensive Cancer Network. (2012). NCCN Clinical Practice Guidelines in Oncology: Myeloid growth factors [v.1.2012]. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp#site
    • National Comprehensive Cancer Network. (2011). NCCN Clinical Practice Guidelines in Oncology: Prevention and treatment of cancer-related infections [v.2.2011]. Retrieved from http://www.nccn.org/professionals/physician_gls/pdf/infections.pdf
  • Cochrane Collaboration
    • Arora, R.S., Roberts, R., Eden, T.O.B., & Pizer, B. (2010). Interventions other than anticoagulants and systemic antibiotics for prevention of central venous catheter-related infections in children with cancer. Cochrane Database of Systematic Reviews, 2010(12). doi:10.1002/14651858.CD007785.pub2
    • Bohlius, J., Herbst, C., Reiser, M., Schwarzer, G., & Engert, A. (2008). Granulopoiesis-stimulating factors to prevent adverse effects in the treatment of malignant lymphoma. Cochrane Database of Systematic Reviews, 2008(4). doi:10.1002/14651858.CD003189.pub4
    • Cheuk, D.K.L., Chiang, A.K.S., Lee, T.L., Chan, G.C.F., & Ha, S.Y. (2011). Vaccines for prophylaxis of viral infections in patients with hematological malignancies. Cochrane Database of Systematic Reviews, 2011(3). doi:10.1002/14651858.CD006505.pub2
    • Gafter-Gvili, A., Fraser, A., Paul, M., Vidal, L., Lawrie, T.A., van de Wetering, M.D., . . . Leibovici, L. (2012). Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy. Cochrane Database of Systematic Reviews, 2012(1). doi:10.1002/14651858.CD004386.pub3
    • Glenny, A.M., Mauleffinch, L.M.F., Pavitt, S., & Walsh, T. (2009). Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer. Cochrane Database of Systematic Reviews, 2009(1). doi:10.1002/14651858.CD006706.pub2
    • Gøtzsche, P.C., & Johansen, H.K. (2002). Routine versus selective antifungal administration for control of fungal infections in patients with cancer. Cochrane Database of Systematic Reviews, 2002(2). doi:10.1002/14651858.CD000026
    • Gurion, R., Belnik-Plitman, Y., Gafter-Gvili, A., Paul, M., Vidal, L., Ben-Bassat, I., . . . Raanani, P. (2011). Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia. Cochrane Database of Systematic Reviews, 2011(9). doi:10.1002/14651858.CD008238.pub2
    • Herbst, C., Naumann, F., Kruse, E.B., Monsef, I., Bohlius, J., Schulz, H., & Engert, A. (2009). Prophylactic antibiotics or G-CSF for the prevention of infections and improvement of survival in cancer patients undergoing chemotherapy. Cochrane Database of Systematic Reviews, 2009(1). doi:10.1002/14651858.CD007107.pub2
    • Johansen, H.K., & Gotzsche, P.C. (2000). Amphotericin B lipid soluble formulations vs amphotericin B in cancer patients with neutropenia. Cochrane Database of Systematic Reviews, 2000(3). doi:10.1002/14651858.CD000969
    • Johansen, H.K., & Gøtzsche, P.C. (2002). Amphotericin B versus fluconazole for controlling fungal infections in neutropenic cancer patients. Cochrane Database of Systematic Reviews, 2002(2). doi:10.1002/14651858.CD000239
    • Jørgensen, K.J., Gøtzsche, P.C., Dalbøge, C.S., & Johansen, H.K. (2014). Voriconazole versus amphotericin B or fluconazole in cancer patients with neutropenia. Cochrane Database of Systematic Reviews, 2014(2). doi:10.1002/14651858.CD004707.pub3
    • Renner, P., Milazzo, S., Liu, J.P., Zwahlen, M., Birkmann, J., & Horneber, M. (2012). Primary prophylactic colony-stimulating factors for the prevention of chemotherapy-induced febrile neutropenia in breast cancer patients. Cochrane Database of Systematic Reviews, 2012(10). doi:10.1002/14651858.CD007913.pub2
    • Schoot, R.A., van Dalen, E.C., van Ommen, C.H., & van de Wetering, M.D. (2013). Antibiotic and other lock treatments for tunnelled central venous catheter-related infections in children with cancer. Cochrane Database of Systematic Reviews, 2013(6). doi:10.1002/14651858.CD008975.pub2
    • van Dalen, E.C., Mank, A., Leclercq, E., Mulder, R.L., Davies, M., Kersten, M.J., & van de Wetering, M.D. (2012). Low bacterial diet versus control diet to prevent infection in cancer patients treated with chemotherapy causing episodes of neutropenia. Cochrane Database of Systematic Reviews, 2012(9). doi:10.1002/14651858.CD006247.pub2
323 titles were selected for a full article review.
 
194 final studies were included after the removal of duplicates and studies that did not meet inclusion criteria and the addition of manuscripts retrieved in other topics meeting prevention of infection-specific criteria.
 
Inclusion Criteria: 
1. Full research report, systematic review, guideline, or meta-analysis
2. Study must report results of measurement of prevention of infection or febrile neutropenia
3. Study examines an intervention aimed at affecting infection or febrile neutropenia
4. Study sample must include patients with cancer
5. Include samples with pediatric cases
6. Include patients undergoing hematopoietic stem cell transplantation (Bone marrow transplant was not previously included in PEP® resources. Search for bone marrow transplant-related studies with a timeframe beginning in 2000.)
7. As of 1/1/2016, additional inclusions are (a) sample size of at least 40 or 20 per study group, and (b) for complex interventions, the description of the intervention must be sufficient to identify the components of that intervention.
 
Exclusion Criteria: 
1. Grey literature
2. Descriptive studies
3. Studies investigating or comparing treatments for febrile neutropenia

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