Antibiotic Prophylaxis in At-Risk Patients

Antibiotic Prophylaxis in At-Risk Patients

PEP Topic 
Prevention of Infection: General

Antibiotic prophylaxis involves the administration of antibiotics prior to any infection in order to prevent infection. Routine antibiotic prophylaxis has been recommended by several professional groups in patients who are at risk for infection, such as those who have an expected duration of severe neutropenia for more than seven days, and patients undergoing hematopoietic cell transplantation (HCT). Flouroquinolones are most often recommended, and have been associated with decreased incidence of febrile neutropenia and infection. Limited evidence exists regarding the use of quinolones in pediatric patients.

Recommended for Practice

Research Evidence Summaries

Systematic Review/Meta-Analysis

Guideline/Expert Opinion