Antibiotic Prophylaxis in at Risk Patients

Antibiotic Prophylaxis in at Risk Patients

PEP Topic 
Prevention of Infection: Transplant

Antibiotic prophylaxis involved the administration of antibiotics prior to any infection in order to prevent infection.  Routine antibiotic prophylaxis has been recommended by several professional groups in patients who are at risk for infection, such as those who have an expected duration of severe neutropenia for longer than seven days and those undergoing hematopoietic cell transplantation.  Fluoroquinolones are most often recommended and have been associated with a decreased incidence of febrile neutropenia and infection.  There is limited evidence regarding the use of quinolones in pediatric patients.

Recommended for Practice

Research Evidence Summaries

Guideline/Expert Opinion

Systematic Review/Meta-Analysis