PEP Topic 

Corticosteroids are a class of steroid hormones produced in the adrenal cortex and involved in a wide range of physiologic systems such as stress and immune responses, regulation of inflammation, carbohydrate metabolism, and protein catabolism. Corticosteroids can be administered orally, intravenously, or topically and are used for a variety of conditions. Drugs in this class include dexamethasone, methylprednisolone, prednisone, hydrocortisone, and fludrocortisones. Corticosteroids have been examined in the management of anorexia and pain, and specific, individual corticosteroids are typically part of drug regimens for chemotherapy-induced nausea and vomiting. Topical use of specific corticosteroids has been examined for its efficacy in radiodermatitis, skin reactions, mucositis, and prevention of bleeding. Systemic use of steroids has been examined in pain, fatigue, radiodermatitis, and skin reactions.

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Systematic Review/Meta-Analysis