Extended- and Sustained-Release Opioids

Extended- and Sustained-Release Opioids

PEP Topic 
Chronic Pain

Sustained-release and extended-release opioids, which make use of time-release formulation, take effect within a specific time. Sustained-release drugs remain in the bloodstream in a stable amount for a longer time than do immediate-release opioids. As a result, patients do not have to take sustained-release medications as often as immediate-release drugs. Sustained-release opioids have been evaluated in the context of chronic cancer-related pain, peripheral neuropathy, and for the relief of dyspnea.

Recommended for Practice

Research Evidence Summaries

Systematic Review/Meta-Analysis

Guideline/Expert Opinion