Neurokinin 1 Receptor Antagonist (NK1)

Neurokinin 1 Receptor Antagonist (NK1)

PEP Topic 
Chemotherapy-Induced Nausea and Vomiting—Adult

Neurokinin 1 (NK1) receptor antagonists are in a class of drug used to treat nausea and vomiting associated with chemotherapy. Aprepitant, casopitant, and fosaprepitant are NK1 drugs. There is some evidence that fosaprepitant may be more helpful in the prevention of delayed nausea and vomiting (dos Santos, Souza, Brunetto, Sasse, & Lima, 2012). NK1 antagonists are effective for both adult and pediatric patients. However, the use and most appropriate dosing among pediatric patients of various age groups has not been determined.

dos Santos, L.V., Souza, F.H., Brunetto, A.T., Sasse, A.D., & Lima, J.P.D.S.N. (2012). Neurokinin-1 receptor antagonists for chemotherapy-induced nausea and vomiting: A systematic review. Journal of the National Cancer Institute, 104, 1280–1292. doi:10.1093/jnci/djs335

Recommended for Practice

Guideline/Expert Opinion

Research Evidence Summaries

Systematic Review/Meta-Analysis