Serotonin 5HT3 Receptor Antagonists (5HT3)

Serotonin 5HT3 Receptor Antagonists (5HT3)

PEP Topic 
Chemotherapy-Induced Nausea and Vomiting—Adult

5-HT3 (5-hydroxytryptamine) receptor antagonists are a class of antiemetic drug used to relieve nausea and vomiting associated with chemotherapy. At this time, four 5-HT3 receptor antagonists are approved by the Food and Drug Administration (FDA) for use in the United States: ondansetron, granisetron, dolasetron, and palonosetron. Some limited evidence suggests that palonosetron may have greater efficacy in prevention of delayed chemotherapy-induced nausea and vomiting (CINV).

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Systematic Review/Meta-Analysis