PEP Topic 
Radiation-Induced Diarrhea

Sucralfate is an ulcer drug that has an anti-inflammatory effect on the gastrointestinal mucosa. The drug causes an increase in the level of prostaglandins and binds basic fibroblast growth factor (bFGF), protecting it from acid degradation. It is angiogenic, increasing blood flow.  Systemic use with oral administration has been studied for diarrhea, mucositis and radiodermatitis. Topical use has been tested as an intervention for radiodermatitis.

Not Recommended for Practice

Guideline/Expert Opinion

Research Evidence Summaries