Use of Live Attenuated Vaccines

Use of Live Attenuated Vaccines

PEP Topic 
Prevention of Infection: Transplant

Live attenuated vaccines contain a form of the living organism that has been weakened so it should not cause disease.  There is the possibility that the living microbe in the vaccine could become virulent and cause disease.  Examples of live attenuated vaccines are intranasal influenza vaccine, varicella vaccine, oral polio vaccine, and measles, mumps, and rubella vaccine.  The potential of attenuated microbes to become virulent is of concern related to the prevention of infection among patients with cancer, especially those who are significantly immunocompromised.

Not Recommended for Practice

Guideline/Expert Opinion