Nes, A.G., & Posso, M.B. (2005). Patients with moderate chemotherapy-induced mucositis: Pain therapy using low intensity lasers. International Nursing Review, 52(1), 68–72.

Laser energy 35 J/cm² once a day for five days after the development of chemotherapy-induced \"moderate\" mucositis.

Laser has an 830 nm wavelength with a potency of 250 mW.  
 

Each patient was informed of the oral hygiene protocol:       
Avoid spicy food acid fruits, alcohol, and food and drinks with high temperature.
Use a soft toothbrush and avoid dental floss.
Only use mouth solution provided by health personnel (3% bicarbonate).
Do not smoke.       

The study was conducted March-August 2002.

Thirteen individuals were treated. Convenience sample for chemo-induced mucositis-related pain.
Mucositis was determined using the Brown methodology. Patients determined to have moderate mucositis (score 13-18) were included in the study.

Non-parametric study

VAS pain scale

Brown methodology for classification of mucositis.
 

Significantly lower pain (p = 0.007) after each treatment. Average pain reduction was 67%. Pain reduction across the five days of treatment was also significant (p = 0.000).

Authors note that after five days, pain is usually reduced to such an extent not to require further treatment.

 Limited sample size, short study – no control

Other factors may have contributed to pain reduction, including normal healing and placebo effect.

Optimal energy level is not determined.

Cost is high, and treatment is not available at most centers.

Main focus of study was on pain .