Proton pump inhibitors reduce the amount of gastric acid secreted in the stomach, resulting in the stabilization of blood clots (Kim et al., 2017; Neumann et al., 2013). Proton pump inhibitors have been used in the treatment of bleeding ulcers and are recommended by current guidelines for management of nonvariceal upper gastrointestinal (GI) bleed and for the prevention of recurrent bleeding in certain patients (Gralnek et al., 2015; Hwang et al., 2012; Kim et al., 2017). 

Gralnek, I.M., Dumonceau, J.M., Kuipers, E.J., Lanas, A., Sanders, D.S., Kurien, M., . . . Racz, I. (2015). Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy, 47(10), a1–a46. https://doi.org/10.1055/s-0034-1393172

Hwang, J.H., Fisher, D.A., Ben-Menachem, T., Chandrasekhara, V., Chathadi, K., Decker, G.A., . . . Fukami, N. (2012). The role of endoscopy in the management of acute non-variceal upper GI bleeding. Gastrointestinal Endoscopy, 75, 1132–1138. https://doi.org/10.1016/j.gie.2012.02.033

Kim, Y.I., Kim, M.J., Park, S.R., Kim, H.K., Cho, S.J., Lee, J.Y., . . . Choi, I.J. (2017). Effect of a proton pump inhibitor on tumor bleeding prevention in unresectable gastric cancer patients: A double-blind, randomized, placebo-controlled trial. Journal of Gastric Cancer, 17, 120–131. https://doi.org/10.5230/jgc.2017.17.e15 

Neumann, I., Letelier, L.M., Rada, G., Claro, J.C., Martin, J., Howden, C.W., . . . Leontiadis, G.I. (2013). Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding. Cochrane Database of Systematic Reviews, 6, CD007999. https://doi.org/10.1002/14651858.CD007999.pub2