Minocycline

Minocycline is a drug that has been traditionally used as an antibiotic and anti-inflammatory. It has been studied in animal models for the prevention of paclitaxel-induced neurotoxicity with some positive results; trials in humans are now underway. Until more results are known, minocycline for peripheral neuropathy should only be used in the context of a clinical trial. 

Pachman, D., Ruddy, K., Lafky, J., Beutler, A., Loprinzi, C., Dockter, T., . . . Sikov, W.M. (2017). A pilot study of minocycline for the prevention of paclitaxel-associated neuropathy: ACCRU study RU221408I. Supportive Care in Cancer, 25, 3407–3416. https://doi.org/10.1007/s00520-017-3760-2

Guideline / Expert Opinion