Calendula is a perennial herb (Calendula officinalis) in the daisy family. Topical use involves use as a tincture or cream. Calendula contains high amounts of flavonoids, plant-based antioxidants that protect the body against cell-damaging free radicals. It seems to have anti-inflammatory, antiviral, and antibacterial effects, as well as healing properties. The healing properties are believed to occur because of increased blood flow to the affected area. Calendula is also available to take orally. Calendula can cause allergic reaction in people sensitive to ragweed and similar plants. Calendula cream has been studied for effectiveness as a topical agent in preventing and managing radiodermatitis and oral mucositis.