Flurbiprofen is a type of nonsteroidal antiinflammatory drug. It is a cyclooxygenase 2 (Cox 2) inhibitor. Cox 2 has been associated with the development of mucositis and flubiprofen in the form of a tooth patch and has been evaluated for the prevention and management of mucositis in patients with cancer.
Stokman, M.A., Spijkervet, F.K., Burlage, F.R., & Roodenburg, J.L. (2005). Clinical effects of flurbiprofen tooth patch on radiation-induced oral mucositis. A pilot study. Supportive Care in Cancer, 13, 42–48.
Tooth patches containing 15 mg flurbiprofen or placebo were applied once a day before sleep to the same natural tooth or the upper denture to the buccal side starting one week prior to radiotherapy (RT) until completion of RT. Treatment was discontinued at the first onset of grade 1 ulceration/pseudomembrane formation.
Oral Mucositis Assessment Scale (OMAS) and World Health Organization (WHO) scoring systems were used to evaluate mucositis. Oral pain, pain on swallowing, global assessment of eating function score, and oral washings for viability of mucosal epithelial cells and maturation were used.