Octenidol® is a mouthwash solution that contains octenidine as an active ingredient, which has antibacterial properties. It does not contain alcohol or chlorhexidine. Octenidine has been shown to have antimicrobial effectiveness as a topical antiseptic agent. Octenidol was tested for its effects on oral mucositis in patients being treated for cancer.
Mutters, N.T., Neubert, T.R., Nieth, R., & Mutters, R. (2015). The role of Octenidol®, Glandomed® and chlorhexidine mouthwash in the prevention of mucositis and in the reduction of the oropharyngeal flora: A double-blind randomized controlled trial. GMS Hygiene and Infection Control, 10, Doc05.
To assess the efficacy of Octenidol®, Glandomed®, and chlorhexidine mouthwash in the prevention of mucositis and the reduction of the oropharyngeal flora
An oral rinse of 100 ml with 50 cc of chlorhexidine or Octenidol was applied to buccal, pharyngeal, gingival, and tooth surfaces for 30 seconds four times per day in the strata 1 group. The strata 2 group used a Glandomed solution 100 ml rinse with 500 cc of Glandomed or Octenidol applied to pharyngeal, gingival, and tooth surfaces for 30 seconds four times a day. Oral swab samples were taken and incubated for 36–48 hours.
Prospective, double-blinded, randomized, controlled study dividing patients into two strata
Both strata showed low OMAS and WHO scores, which did not differ significantly between the groups. Overall oropharyngeal flora was significantly reduced in the Octenidol group compared to the chlorhexidine and Glandomed groups.
All solutions resulted in low grades of mucositis according to the OMAS and WHO scoring systems. Octenidol reduced oropharyngeal flora more than chlorhexidine and Glandomed.
In this study, Octenidol proved to be superior to chlorhexidine and Glandomed in reducing oropharyngeal flora. This could potentially reduce the occurrence of hospital-acquired infections and ventilator-associated pneumonia.