STEPP (Skin Toxicity Evaluation Protocol With Panitumumab) refers to a set combination of interventions aimed at the prevention of skin toxicity. The protocol began a day prior to chemotherapy administration and comprised skin moisturizer used daily, sunscreen (sun protection factor [SPF] ≥ 15 with both ultraviolet A [UVA] and ultraviolet B [UVB] protection) applied prior to going outdoors, topical steroid applied to various skin areas at bedtime, and doxycycline 100 mg taken BID. This protocol was used prophylactically rather than as a provision of interventions in response to treatment-related side effects or toxicities.