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Immediate Release Opioids (Systemic)

Opioids are narcotic analgesics. Immediate-release opioids, which are fast acting, have been evaluated for its usefulness in relieving dyspnea in patients with cancer and other palliative care patients with dyspnea symptoms. Fentanyl, a type of opioid, is considered separately in the categorization of relevant evidence for dyspnea treatment. Healthcare professionals should be aware of the different formulations for these medications, the length of their half-life, and the onset of action.

Hypogastric Neurolysis

Neural block of the hypogastric plexus involved injection of an anesthetic solution into the superior hypogastric plexus. This procedure has been tested for effectiveness in pain relief for patients with cancer pain in the pelvis.


hypnotic state is a state between wakefulness and sleep, a state of heightened concentration and receptivity that results in suspension of peripheral cues. The effect of a hypnotic state results in alteration of perception and attention. Hypnosis has been tested for its effect on pain, anxiety, depression, chemotherapy-induced nausea and vomiting (CINV), hot flashes, and fatigue in patients with cancer.

Hypnosis for Anticipatory CINV

Hypnosis is a state between wakefulness and sleep, a state of heightened focal concentration and receptivity, an altered state of consciousness of a state of focused attention that results in suspension of peripheral cues. The effect of a hypnotic state results in alteration in perception and attention. Hypnosis has been tested for effect in pain, anxiety, depression, chemotherapy-induced nausea and vomiting (CINV), hot flashes, and fatigue in patients with cancer.

Hydrophillic Foam Dressing

Hydrophillic foam dressing is self-adhering and has a silicone absorbant foam layer bonded to a polyurethane or similar type of backing. The dressing differs from hydrocolloid dressings in that the hydrophyllic foam dressing does not contain chemicals that turn into a gel over time and the foam layer may provide some protection of the site.

Hydrocolloid and Hydrogel Dressings

Hydrocolloid dressings are wound dressings that are occlusive and adhesive and can form a gel with water. Hydrogel dressings have similar properties in a gel consistency. Various hydrocolloid gels and dressings have been used in wound management to maintain moisture and aid in debridement of necrotic tissue. These dressings have been evaluated in patients with cancer for management of radiodermatitis with moist desquamation and in patients with cutaneous toxicities.

Hyaluronic Acid/Sodium Hyaluronate

Hyaluronic acid, also known as hyaluronate, is a carbohydrate substance that is present in connective, epithelial, and neural tissues and is a major component of the intracellular matrix. Sodium hyaluronate is the sodium salt of the same substance. Hyaluronic acid or sodium hyaluronate has been used in patients with cancer as an oral spray for treatment of mucositis and as a topical treatment for radiodermatitis.


A humidifier increases the amount of moisture in the air in a room or a building. Air that is too dry may dry out mucous membranes and cause these tissues to be irritated. Personal humidifiers, worn at night, have been investigated in patients with cancer treatment-related mucositis as a way to promote the healing of mucus membranes. 

Human Leukemia Inhibitory Factor

Human leukemia inhibitory factor (LIF) is an interleukin class cytokine that inhibits cell differentiation. Recombinant human LIF was evaluated for its effect on chemotherapy-induced peripheral neuropathy in patients with cancer.

Human Intestinal Trefoil Factor

Intestinal trefoil factor is a peptide that is found in mucosal goblet cells and plays a role in mucosal defense and repair. Topical use of recombinant human intestinal trefoil factor was evaluated for its effect in patients with cancer for the prevention and management of mucositis.

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