Quality of Life of Family Caregivers of Patients With Cancer: A Literature Review

Luppana Kitrungrote

Marlene Z. Cohen

ONF 2007, 33(3), 625-632. DOI: 10.1188/06.ONF.625-632

Purpose/Objectives: To systematically review literature regarding the quality of life (QOL) of family caregivers of patients with cancer and evaluate the instruments measuring family caregivers' QOL.

Data Sources: PubMed, CINAHL®, PsycINFO, ISI Web of Science®, and EBSCO electronic databases; published literature.

Data Synthesis: Overall, the QOL of family caregivers of patients with cancer varied. Influences related to family caregivers' QOL were identified. Global and generic measures have been used because of the lack of specific instruments. Comparisons are complicated because several measures were used at different times along the illness trajectory with caregivers caring for people with various types and stages of cancer.

Conclusions: A more explicit definition of QOL for family caregivers of patients with cancer and specific instruments suitable for different cultures are needed to enhance knowledge.

Implications for Nursing: Maintaining the QOL of caregivers is important in their ability to provide the care required to keep family members with cancer in the community. Nurses must provide care to maintain caregivers' QOL.

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    Axelsson, B., & Sjoden, P.O. (1998). Quality of life of cancer patients and their spouses in palliative home care. Palliative Medicine, 12, 29-39.
    Borneman, T., Chu, D.Z., Wagman, L., Ferrell, B., Juarez, G., McCahill, L.E., et al. (2003). Concerns of family caregivers of patients with cancer facing palliative surgery for advanced malignancies. Oncology Nursing Forum, 30, 997-1005.
    Boyle, D., Blodgett, L., Gnesdiloff, S., White, J., Bamford, A.M., Sheridan, M., et al. (2000). Caregiver quality of life after autologous bone marrow transplantation. Cancer Nursing, 23, 193-203.
    Campbell, L.C., Keefe, F.J., McKee, D.C., Edwards, C.L., Herman, S.H., Johnson, L.E., et al. (2004). Prostate cancer in African Americans: Relationship of patient and partner self-efficacy to quality of life. Journal of Pain and Symptom Management, 28, 433-444.
    Cantril, H. (1965). The pattern of human concerns. New Brunswick, NJ: Rutgers University Press.
    Chen, M.L., Chu, L., & Chen, H.C. (2004). Impact of cancer patients' quality of life on that of spouse caregivers. Supportive Care in Cancer, 12, 469-475.
    Chung, M.C., Killingworth, A., & Nolan, P. (1997). A critique of the concept of quality of life. International Journal of Health Care Quality Assurance, 10(2), 80-84.
    Crowe, H., & Costello, A.J. (2003). Prostate cancer: Perspectives on quality of life and impact of treatment on patients and their partners. Urologic Nursing, 23, 279-285.
    Day, H., & Jankey, S.G. (1996). Lessons from the literature: Toward a holistic model of quality of life. In R. Renwick, I. Brown, & M. Nagler (Eds.), Quality of life in health promotion and rehabilitation (pp. 39-62). Thousand Oaks, CA: Sage.
    Farquhar, M. (1995). Definition of quality of life: A taxonomy. Journal of Advanced Nursing, 22, 502-508.
    Ferrans, C.E. (1990). Quality of life: Conceptual issues. Seminars in Oncology Nursing, 6, 248-254.
    Ferrans, C.E. (2000). Quality of life as an outcome of cancer care. In C.H. Yarbro, M.H. Frogge, M. Goodman, & S.L. Groenwald (Eds.), Cancer nursing: Principles and practice (5th ed., pp. 243-258). Sudbury, MA: Jones and Bartlett.
    Ferrell, B.R., Dow, K.H., Leigh, S., Ly, J., & Gulasekaram, P. (1995). Quality of life in long-term cancer survivors. Oncology Nursing Forum, 22, 915-922.
    Frank-Stromborg, M. (1997). Instruments for clinical nursing research (2nd ed.). Sudbury, MA: Jones and Bartlett.
    Gaston-Johansson, F., Lachica, E.M., Fall-Dickson, J.M., & Kennedy, M.J. (2004). Psychological distress, fatigue, burden of care, and quality of life in primary caregivers of patients with breast cancer undergoing autologous bone marrow transplantation. Oncology Nursing Forum, 31, 1161-1169.
    Gill, P., Kaur, J.S., Rummans, T., Novotny, P.J., & Sloan, J.A. (2003). The hospice patient's primary caregiver: What is their quality of life? Journal of Psychosomatic Research, 55, 445-451.
    Given, B.A., Given, C.W., & Kozachik, S. (2001). Family support in advanced cancer. CA: A Cancer Journal for Clinicians, 51, 213-231.
    Hagedoorn, M., Buunk, B.P., Kuijer, R.G., Wobbes, T., & Sanderman, R. (2000). Couples dealing with cancer: Role and gender differences regarding psychological distress and quality of life. Psycho-Oncology, 9, 232-242.
    Hahn, C.A., Dunn, R.H., Logue, P.E., King, J.H., Edwards, C.L., & Halperin, E.C. (2003). Prospective study of neuropsychologic testing and quality of life assessment of adults with primary malignant brain tumors. International Journal of Radiation Oncology, Biology, Physics, 55, 992-999.
    Harding, R., & Higginson, I.J. (2003). What is the best way to help caregivers in cancer and palliative care? A systematic literature review of interventions and their effectiveness. Palliative Medicine, 17, 63-74.
    Iconomou, G., Viha, A., Kalofonos, H.P., & Kardamakis, D. (2001). Impact of cancer on primary caregivers of patients receiving radiation therapy. Acta Oncologica, 40, 766-771.
    Jacobson, S.F. (2004). Evaluating instruments for use in clinical nursing research. In M. Frank-Stromborg, & S.J. Olsen (Eds.), Instruments for clinical health-care research (3rd ed., pp. 3-19). Sudbury, MA: Jones and Bartlett.
    Kershaw, T., Northouse, L., Kritpracha, C., Schafenacker, A., & Mood, D. (2004). Coping strategies and quality of life in women with advanced breast cancer and their family caregivers. Psychology and Health, 19(2), 139-155.
    Koot, R.W., de Heer, K., Oort, F.J., Hulshof, M.C., Bosch, D.A., & de Haes, J.C. (2004). Quality of life after brachytherapy in patients with glioblastoma multiforme. European Journal of Cancer, 40, 1013-1020.
    Kornblith, A.B., Herndon, J.E., Zuckerman, E., Godley, P.A., Savarese, D., Vogelzang, N.J., et al. (2001). The impact of docetaxel, estramustine, and low dose hydrocortisone on the quality of life of men with hormone refractory prostate cancer and their partners: A feasibility study. Annals of Oncology, 12, 633-641.
    Kornblith, A.B., Herr, H.W., Ofman, U.S., Scher, H.I., & Holland, J.C. (1994). Quality of life of patients with prostate cancer and their spouses. The value of a data base in clinical care. Cancer, 73, 2791-2802.
    Le, T., Leis, A., Pahwa, P., Wright, K., Ali, K., Reeder, B., et al. (2004). Quality of life evaluations of caregivers of ovarian cancer patients during chemotherapy treatment. Journal of Obstetrics and Gynaecology Canada, 26, 627-631.
    Mathieson, C.M., Stam, H.J., & Scott, J.P. (1991). The impact of a laryngectomy on the spouse: Who is better off? Psychology and Health, 5, 153-163.
    Matthews, B.A., Baker, F., & Spillers, R.L. (2004). Family caregivers' quality of life: Influence of health protective stance and emotional strain. Psychology and Health, 19, 625-641.
    McMillan, S.C. (1996). Quality of life of primary caregivers of hospice patients with cancer. Cancer Practice, 4(4), 191-198.
    McMillan, S.C., & Mahon, M. (1994). The impact of hospice services on the quality of life of primary caregivers. Oncology Nursing Forum, 21, 1189-1195.
    Meyers, J.L., & Gray, L.N. (2001). The relationships between family primary caregiver characteristics and satisfaction with hospice care, quality of life, and burden. Oncology Nursing Forum, 28, 73-82.
    Nijboer, C., Triemstra, M., Tempelaar, R., Sanderman, R., & van den Bos, G.A. (1999). Determinants of caregiving experiences and mental health of partners of cancer patients. Cancer, 86, 577-588.
    Northouse, L.L., Mood, D., Kershaw, T., Schafenacker, A., Mellon, S., Walker, J., et al. (2002). Quality of life of women with recurrent breast cancer and their family members. Journal of Clinical Oncology, 20, 4050-4064.
    Padilla, G.V., & Frank-Stromborg, M. (1997). Single instruments for measuring quality of life. In M. Frank-Stromborg & S.J. Olsen (Eds.), Instruments for clinical health-care research (2nd ed., pp. 114-132). Sudbury, MA: Jones and Bartlett.
    Smeenk, F.W., de Witte, L.P., van Haastregt, J.C., Schipper, R.M., Biezemans, H.P., & Crebolder, H.J. (1998). Transmural care of terminal cancer patients: Effects on the quality of life of direct caregivers. Nursing Research, 47(3), 129-136.
    Stetz, K.M. (2003). Quality of life in families experiencing cancer. In C.R. King & P.S. Hinds (Eds.), Quality of life: From nursing and patient perspectives (pp. 219-238). Sudbury, MA: Jones and Bartlett.
    Tuinman, M.A., Fleer, J., Hoekstra, H.J., Sleijfer, D.T., & Hoekstra-Weebers, J.E. (2004). Quality of life and stress response symptoms in long-term and recent spouses of testicular cancer survivors. European Journal of Cancer, 40, 1696-1703.
    Vickery, L.E., Latchford, G., Hewison, J., Bellew, M., & Feber, T. (2003). The impact of head and neck cancer and facial disfigurement on the quality of life of patients and their partners. Head and Neck, 25, 289-296.
    Waltz, C.F., Strickland, O.L., & Lenz, E.R. (1991). Measurement in nursing research (2nd ed.). Philadelphia: F.A. Davis.
    Weitzner, M.A., Jacobsen, P.B., Wanger, H., Jr., Friedland, J., & Cox, C. (1999). The Caregiver Quality of Life Index-Cancer (CQOLC) Scale: Development and validation of an instrument to measure quality of life of the family caregiver of patients with cancer. Quality of Life Research, 8, 55-63.
    Weitzner, M.A., McMillan, S.C., & Jacobsen, P.B. (1999). Family caregiver quality of life: Differences between curative and palliative cancer treatment settings. Journal of Pain and Symptom Management, 17(6), 418-428.
    Weitzner, M.A., Meyers, C.A., Steinbruecker, S., Saleeba, A.K., & Sandifer, S.D. (1997). Developing a caregiver quality-of-life instrument: Preliminary steps. Cancer Practice, 5(1), 25-31.
    Zacharias, D.R., Gilg, C.A., & Foxall, M.J. (1994). Quality of life and coping in patients with gynecologic cancer and their spouses. Oncology Nursing Forum, 21, 1699-1706.