ONS White Paper Reviews State of the Knowledge on Neutropenia

In "Neutropenia: State of the Knowledge," a two-part ONS white paper, the authors identify what currently is known and, importantly, not known about the most common dose-limiting toxicity of cancer chemotherapy: chemotherapy-induced neutropenia (CIN).

In Part I, project team members of the State of the Knowledge on Neutropenia Symposium summarize the evidence regarding CIN and discuss neutrophil physiology, chemotherapy dose intensity, approaches to risk assessment, national practice guidelines, and outcomes of neutropenia.

Part II presents the results of the team’s literature review and discussion at the symposium pertaining to nursing interventions for infection prevention, patient education, health policy, and gaps in clinical research. Conclusions and discussion from the entire project are summarized with recommendations for practice, education, and research.