Vincristine Has Broad Use in Oncology Setting

Vincristine sulfate for injection is the salt of an alkaloid from the flowering periwinkle plant (also known as Vinca rosea Linn). It was originally known as leurocristine and is now sometimes also referred to as LCR or VCR. The trade name for vincristine is Vincasar PFS®; the drug is also commonly known as Oncovin.

Vincristine is used for the treatment of a number of types of cancerous conditions, and is FDA-approved for patients with the following cancers.

  • Acute lymphoblastic leukemia
  • Non-Hodgkin lymphomas (lymphocytic, mixed cell, histiocytic, undifferentiated, nodular, and diffuse types)
  • Hodgkin disease
  • Rhabdomyosarcoma
  • Neuroblastoma
  • Wilms tumor

It is important to keep in mind that physicians also have the authority to prescribe drugs for conditions other than those for which the drug has been FDA approved; therefore, vincristine sulfate may sometimes be used in the treatment of breast cancer, small-cell lung cancer, or other cancers (Polovich, Whitford, & Olsen, 2009).


Polovich, M., Whitford, J.M., & Olsen, M. (Eds.). (2009). Chemotherapy and biotherapy guidelines and recommendations for practice (3rd ed.). Pittsburgh, PA: Oncology Nursing Society.