DiPalma, J.A., Cleveland, M.V., McGowan, J., & Herrera, J.L. (2006). An open-labeled study of chronic polyethylene glycol laxative use in chronic constipation. Alimentary Pharmacology and Therapeutics, 25, 703–708.doi: 10.1111/j.1365-2036.2006.03228.x
To extend the safety data of polyethylene glycol used for chronic treatment of chronic constipation.
Polyethylene glycol laxative was administered as a single daily dose of 17 g for 12 months.
This was a randomized, open-label, single-treatment study.
Polyethylene glycol laxative is safe and effective for treating constipation in adult and older adult patients for periods up to 12 months, with no evidence of tachyphylaxis.