DiPalma, J.A., Cleveland, M.B., McGowan, J., & Herrera, J.L. (2007a). A comparison of polyethylene glycol laxative and placebo for relief of constipation from constipating medications. Southern Medical Journal, 100, 1085–1090.doi: 10.1097/SMJ.0b013e318157ec8f
To compare the safety and efficacy of polyethylene glycol (PEG) 3350 (Miralax®) versus placebo for treatment of constipation in patients with chronic constipation.
PEG 3350 laxative 17 g or placebo was administered daily for 28 days. Use of nonconstipating medications was allowed, but the use of fiber or other laxatives was not permitted. Patients received a 4 L jug containing Crystal Light® with or without study medication. The mixture was reconstituted by unblinded study personnel; investigators remained blinded. A daily bowel diary was used to share bowel movement (BM) experiences and answer questions related to study efficacy and safety criteria. Laboratory evaluation was repeated at study conclusion.
Four centers in the United States
This was a double-blind, placebo-controlled, parallel, randomized controlled trial.
PEG is safe and effective in treating constipation in patients taking constipating medications.