Kienzle-Horn, S., Vix, J.M., Schuitjt, C., Peil, H., Jordan, C.C., & Kamm, M.A. (2007). Comparison of bisacodyl and sodium picosulfate in the treatment of chronic constipation. Current Medical Research and Opinion, 23, 691–699.doi: 10.1185/030079907X178865
To compare the safety and efficacy of bisacodyl and sodium picosulphate.
Patients received 5 to 10 mg of bisacodyl sugar-coated tablets or sodium picosulphate drops daily over four weeks. The study schedule included four visits: an initial screening visit followed by a seven-day baseline period, a randomization visit (1:1 basis) and two follow-up visits on days 15 and 29.
15 centers (outpatient clinics and specialist gastroenterology units) in Germany
This was a phase IV, open-label, randomized, parallel group study.
Bisacodyl and sodium picosulphate are equally tolerated and effective in the treatment of chronic constipation.