Clemens, K.E., & Klaschik, E. (2007). Symptomatic therapy of dyspnea with strong opioids and its effect on ventilation in palliative care patients. Journal of Pain and Symptom Management, 33(4), 473–481.doi: 10.1016/j.jpainsymman.2006.09.015
The objective of this study was
One opioid dose of morphine (mean dose 9.4 mg [SD = 8.8 mg]) or hydromorphone (morphine equivalent dose of 10.8 mg [SD = 3.8 mg])
The sample was comprised of 11 patients with dyspnea (5 severe, 4 moderate, and 2 mild), 8 patients with lung cancer, 2 patients with breast cancer, and 1 patient with acute lymphoblastic leukemia. None of the patients had a history of chronic obstructive pulmonary disease.Two patients were pretreated with opioids for pain control.
The study was conducted on an inpatient palliative care unit.
The study was a prospective, nonrandomized, uncontrolled trial.
After opioid administration
Patients’ ratings showed no significant decrease in dyspnea intensity with nasal oxygen.
Decreased respiratory rate and decreased dyspnea scores with opioid dose were evident.