Liguori, V., Guillemin, C., Pesce, G.F., Mirimanoff, R.O., & Bernier, J. (1997). Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiotherapy and Oncology, 42, 155–161.doi: 10.1016/S0167-8140(96)01882-8
To determine if prophylactic use of hyaluronic acid cream postpones acute radiodermatitis or reduces its severity and to evaluate the efficacy of hyaluronic acid to delay the onset of necrosis or to accelerate recovery in case of ulceration
Hyaluronic or placebo cream was applied to irradiated skin area twice daily. The first application was one-to-two hours after the radiation therapy session and the second was in the evening. The topic treatment was continued over a six-week period.
The study took place at Ospedale San Giovanni and Centre Hospitlier Universitaire, both in Switzerland.
The study used a randomized placebo-controlled double-blind trial design.
The prophylactic use of hyaluronic acid cream is shown to reduce the incidence of high-grade radiodermatitis.