Peterson, D.E., Jones, J.B., & Petit, R.G., II. (2007). Randomized, placebo-controlled trial of Saforis for prevention and treatment of oral mucositis in breast cancer patients receiving anthracycline-based chemotherapy. Cancer, 109, 322–331.doi: 10.1002/cncr.22384
The study was conducted in Russia.
This was a randomized, double-blind, placebo-controlled, crossover, phase III trial.
Glutamine is easy to use, has a favorable safety profile, and is low in cost. The total daily dose was within the range of dietary glutamine consumed by an adult on a high-protein diet (about 8 g per day). This treatment should be tested in higher intensity chemotherapy regimens.