Hejna, M., Kostler, W.J., Raderer, M., Steger, G.G., Brodowicz, T., Scheithauer, W., … Zielinski, C.C. (2001). Decrease of duration and symptoms in chemotherapy-induced oral mucositis by topical GM-CSF: Results of a prospective randomized trial. European Journal of Cancer, 37, 1971–1975.doi: 10.1016/S0959-8049(01)00132-0
Patients were randomized to one of two arms.
Both groups were instructed to continue using the respective mouthwashes until complete response (CR). A third, independent investigator randomized patients without knowing individual mucositis ratings.
The study was conducted between March 1998 and June 1999.
This was a prospective, randomized, controlled study.
Every three days, objective and subjective evaluations were conducted.