Castagna, L., Benhamou, E., Pedraza, E., Luboinski, M., Forni, M., Brandes, I., … Dietrich, P.-Y. (2001). Prevention of mucositis in bone marrow transplantation: A double blind randomised controlled trial of sucralfate. Annals of Oncology, 12, 953–955.doi: 10.1023/A:1011119721267
To compare placebo to sucralfate for prevention of mucositis in high-dose chemotherapy and bone marrow transplant (BMT)
Treatment was started one day before the regimen. Patients received one 2 g dose pack every three hours during the day and once during the night if awakened for a maximum of 7 per 24 hours until bone marrow (BM) recovery or end of mucositis.
The study reported on 102 patients hospitalized for allogeneic or autologous BMT.
The study was conducted between April 1991 and November 1993.
This was a prospective, randomized, double-blind study.
Patients were examined twice weekly by two physicians only, recorded prospectively, according to adapted Oral and Maxillofacial Surgeon (OMS) criteria for grafted patients.