Nauseef, W. M., & Maki, D. G. (1981). A study of the value of simple protective isolation in patients with granulocytopenia. New England Journal of Medicine, 304, 448–453.doi: 10.1056/NEJM198102193040802
To evaluate protective isolation versus no isolation.
The authors evaluated single protective isolation (single-bed room and clean gowns, gloves, and masks for people entering room) versus standard care (two-bed room and reminder sign to wash hands).
Forty-three episodes of neutropenia occurred in adult patients.
This was a randomized study.
No significant difference was found between isolated and nonisolated patients regarding the incidence of infection, time of onset of first infection, and days with fever.