Newton, P.J., Davidson, P.M., Macdonald, P., Ollerton, R., & Krum H. (2008). Nebulized furosemide for the management of dyspnea: Does the evidence support its use? Journal of Pain & Symptom Management, 36(4), 424-441.doi: 10.1016/j.jpainsymman.2007.10.017
The objective of the study is to synthesize information regarding the effect of nebulized furosemide in managing dyspnea.
The final sample included 42 articles, including 39 randomized controlled trials; 2 studies in cancer, 35 in asthma, 8 studies in health volunteers, and 1 in chronic obstructive pulmonary disease.
Dyspnea was only measured in five studies reviewed.
This review demonstrates a lack of strong evidence in the area of nebulized furosemide for dyspnea and little evidence was found in the management of dyspnea in patients with cancer.