Auret, K., Roger Goucke, C., Ilett, K.F., Page-Sharp, M., Boyd, F., & Oh, T.E. (2006). Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain. Therapeutic Drug Monitoring, 28, 359–366.doi: 10.1097/01.ftd.0000211827.03726.e4
To elucidate the pharmacology of methadone in palliative care patients with advanced cancer who have switched from morphine to methadone
The study had a small sample size.
Further studies, to determine if methadone is better than morphine for the treatment of neuropathic pain, are warranted.