Duran, M., Perez, E., Abanades, S., Vidal, X., Saura, C., Majem, M., … Capella, D. (2010). Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. British Journal of Clinical Pharmacology, 70, 656–663.doi: 10.1111/j.1365-2125.2010.03743.x
To evaluate the effect, toleration, and pharmacokinetics of dose titration of cannabis oral spray added to standard therapy to control chemotherapy-induced nausea and vomiting (CINV) in patients receiving a moderately emetogenic regimen
They study was conducted at multiple outpatient settings in Barcelona, Spain.
All patients were in active treatment.
This was a randomized, double-blind, placebo-controlled, parallel, phase-II trial.
Complete response was defined as no vomiting and a mean nausea score of ≤ 10 mm.
Partial response was defined as vomiting 1-4 times daily and a mean nausea score of ≤ 25 mm on a 100-mm visual analogue scale (VAS).
The following additional measurement instruments were used.
The addition of this formulation of Cannabis to standard antiemetic treatment appears to improve control of delayed nausea and vomiting with MEC.