Grover, V.K., Mathew, P.J., Yaddanapudi, S., & Sehgal, S. (2009). A single dose of preoperative gabapentin for pain reduction and requirement of morphine after total mastectomy and axillary dissection: Randomized placebo-controlled double-blind trial. Journal of Postgraduate Medicine, 55(4), 257–260.doi:10.4103/0022-3859.58928
To investigate the effect of a single low dose (600 mg) of preoperative oral gabapentin on morphine consumption after total mastectomy and axillary dissection; to determine if the specified administration of gabapentin is safe
Before total mastectomy and axillary dissection, patients received 600 mg gabapentin or placebo. Pain, sedation, nausea, vomiting, and side effects were monitored every 30 minutes for 2 hours and then every 2 hours until 12 hours after surgery.
Randomized double-blind placebo-controlled trial
Pre-emptive administration of a single oral dose of gabapentin, 600 mg, led to a decrease in the use of postoperative analgesic.
The use of preoperative gabapentin was associated with improved pain control and quality of life, without excessive side effects.