Steroids are a type of compound that contains a characteristic chemical structure. Steroid drugs have anti-inflammatory activity. Topical steroids have been examined for effectiveness in the management of skin reactions and pruritus that may occur as part of skin reactions. Steroids applied topically can be absorbed and have systemic effects. The amount absorbed depends on the frequency and duration of application, the strength of the steroid preparation, the amount applied, and the application surface. Systemic absorption is greater if skin integrity is compromised in the application area. Significant absorption can cause any of the side effects associated with steroids. Side effects are most common in children and older adults.