Low level laser therapy (LLLT) involves the use of a handheld infrared laser in an attempt to affect cells and physical symptoms often related to inflammation. This therapy has been approved by the U.S. Food and Drug Administration for treatment of post-mastectomy lymphedema. LLLT has also been evaluated for the prevention and treatment of mucositis in patients receiving stem cell transplantation conditioning or radiation therapy to the oral cavity area. For mucositis, LLLT is defined as a wavelength at 650 nm, power of 40 mW, and each square centimeter treated with sufficient time to deliver a tissue energy dose of 2 J/cm2.  

Lalla, R.V., Bowen, J., Barasch, A., Elting, L, Epstein, J., Keefe, D.M., . . . Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology. (2014). MASCC/ISOO evidence based clinical practice guidelines for mucositis secondary to cancer therapy. Cancer, 120, 1453–1461. doi:10.1002/cncr.28592