Novel Approaches

The MarginProbe® System: An Innovative Approach to Reduce the Incidence of Positive Margins Found After Lumpectomy

Sowsina Gola

Susan Doyle-Lindrud

MarginProbe® System, breast cancer, lumpectomy, tumor margins
CJON 2016, 20(6), 598-599. DOI: 10.1188/16.CJON.598-599

The goal of lumpectomy surgery for breast cancer is to completely remove the tumor and have clear margins, reducing the rates of local recurrence. The MarginProbe® System is a new device that can detect microscopic tumor cells at or close to the margin of the surgical resection intraoperatively, providing the surgeon with the ability to re-excise tissue at the time of surgery, reducing the need for a second surgery to obtain clear margins.

At a Glance

  • Lumpectomy surgery followed by radiation is the recommended treatment for early-stage breast cancer; however, successful lumpectomy is contingent upon cancer-free surgical margins.
  • Current standards of intraoperative margin assessments include visual inspection, palpation, and imaging techniques, which are all less than reliable.
  • The MarginProbe® System, used during lumpectomy surgery, has been shown to reduce the need for a second surgery because of positive tumor margins.
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