Multiple myeloma accounts for 10% of all hematologic malignancies. It has been drawn to the forefront of clinical interest because of recent advances in treatment regimens. Although there are multiple lines of available therapies and ongoing clinical trials, autologous stem cell transplantation remains the central option for prolonging durations of remission and improving overall survival. This case study demonstrates how oncology nurses play a critical role in patients’ journeys before and after autologous stem cell transplantation.