Redd, W.H., Montgomery, G.H., & DuHamel, K.N. (2001). Behavioral intervention for cancer treatment side effects. Journal of the National Cancer Institute, 93, 810-823.

Databases searched were National Library of Medicine PubMed database, which includes MEDLINE, PreMedline, and other related databases (1979-January, 2000).
Search keywords were cancer and behavior, intervention, nausea, vomit, depression, anxiety, fatigue, neuro, cognitive, menopause, sex, and post-traumatic stress disorder.
Studies were included if they were randomized controlled studies, within-subject studies, or case reports.

The review consisted of 54 studies that met the criteria.
Three symptom clusters were evaluated. The review included published reports for nausea and vomiting, anxiety/stress, and pain.
For the nausea and vomiting review, studies must have addressed
- Cancer-related treatment side effect with behavioral intervention
- Cancer-treatment intervention effects.

The following treatments were evaluated: relaxation, hypnosis, cognitive/attentional distraction, desensitization, and rehearsal modeling.
Four studies for relaxation and hypnosis showed effectiveness of behavioral intervention for control of anticipatory nausea and vomiting (no anticipatory vomiting occurred).
Results from the individual analyses were confirmed in 12 of 13 randomized-controlled trials that compared behavioral interventions with no treatment/attention control conditions.
The impact of behavioral intervention on postchemotherapy side effects was less established, with four studies reporting that the behavioral intervention reduced the intensity of the postchemotherapy side effects but did not prevent their occurrence.

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