The infusion of calcium and magnesium via IV during neurotoxic chemotherapy cycles has been evaluated for its effect on the prevention of peripheral neuropathy. It has been thought that acute neuropathic symptoms may be a result of certain chemotherapy agents bonding to calcium. Some neurotoxic agents also may result in hypomagnesemia. Infusion of calcium gluconate and magnesium sulfate immediately before and after chemotherapy administration has been evaluated for an effect in the prevention of peripheral neuropathy.