Chlorhexidine is an antiseptic that has a broad-spectrum effect against gram-positive and -negative bacteria. The use of chlorhexidine solution for skin preparation prior to central line insertion and for routine central venous catheter care has been evaluated for its effects in the prevention of central line infection, and it is generally included as part of central venous catheter care bundles.

Nurses need to be aware that, although rare, severe allergic skin reactions to chlorhexidine gluconate have been reported. Nurses should ask patients if they have had any prior skin reaction to this product before use. See relevant FDA information.